Changing the exhaust and intake will cause changes in how air flows into and out of the engine. Engines are at their core just air pumps, after all. Much of these changes can be accounted for by the closed loop O2 sensor feedback system. You would have to make much more extreme changes to fall out of the range of what the PCM can account for, which changes to intake and exhaust won't do. If you disabled closed-loop feedback or you just want to adjust the tables yourself, then get a wideband O2 sensor and get to doing your own tuning. There's no magic bullet. But if the question is just "will I blow up my engine if I use the Corvette tables," the answer is no.
No, reducing the knock sensors from 2 to 1 won't cause detonation. On the 94-95 $EE PCMs, whether you have one sensor or two there's only actually one channel being used on the PCM end (the 96-97 PCM used two channels). What's important with regards to the knock feedback system is not the number of sensors, but is rather the calibration stored on the knock module inserted into the PCM. This module is what takes the output from the knock sensor(s) and filters it to tell the PCM when knock is occuring. Making changes to the acoustic profile for your engine will cause this knock feedback system to malfunction, but it's not the fault of the sensor. It's the knock module.
Unfortunately, short of designing your own knock module, you're not going to be able to get around this. Once you start doing custom work in your engine bay, it's best to just disable the knock feedback system entirely and rely on proper tuning, or run an external knock feedback system if you're paranoid.