I'm using aftermarket standalone EFI on a completely junkyard parts, used, 2nd hand and Ebay built roots supercharged engine. It helps that the original vehicle the supercharger and intake manifolds came from was EFI so it already had injectors and throttlebody design.
BMW 4.4L V8 with a Jaguar Eaton M112 supercharger:
I would imagine a TBI supercharged engine would be rather straight forward.
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